The UN special envoy for Syria, Geir Pedersen, warned April 25 of grave consequences for the country's future without genuine political inclusion and urgent economic support for a successful political transition. During a briefing to the Security Council, Pedersen noted the legacies of misrule, conflict and exclusion in Syria, stating:

This means that the situation is inherently still extremely fragile. The vital ingredients to address this fragility are clear: we need genuine political inclusion so that all Syrians can participate meaningfully in shaping their country's political future, along with countering extremism and terrorism; and real support from the international community to give this transition a chance to succeed against great odds.

It was tragically appropriate that the second anniversary of Sudan's devastating civil war was marked by yet another massacre. At least 400 people were killed when the paramilitary Rapid Support Forces (RSF) overran the Zam Zam displacement camp in North Darfur on April 11. They also executed 10 staff members in the camp's last remaining clinic, including medics and ambulance drivers. Eighty percent of the camp's original 500,000 population has escaped to the nearby government-held town of el-Fasher, although the RSF is believed to be trying to stop people—especially young men—from leaving.

The Office of the United Nations High Commissioner for Human Rights (OHCHR) expressed concern on April 11 over the legality of recent Israeli evacuation orders under international humanitarian law, citing fears over the permanent displacement of Palestinians from the Gaza Strip. 

Since resuming hostilities on March 18, Israel has issued 21 "evacuation orders." On March 31, the Israeli military issued an order covering almost all of Rafah, the Strip's southernmost governorate, followed by a large-scale ground operation in the area. Tens of thousands of Palestinians were already reportedly trapped in Rafah, with no way out and no access to humanitarian aid.

Some of the world's poorest countries, including nations grappling with protracted humanitarian crises, are among those most affected by US President Donald Trump's new trade tariffs regime, which has compounded pre-existing economic strains and debt woes. Asian markets will be particularly hard hit, including imports to the US from Myanmar to be charged at 45%, and Bangladesh at 37%. Big charges were also imposed on fragile economies in the Middle East and North Africa, with Syria at 41%, Libya at 31%, and Iraq at 39%. But among the worst effects will likely be felt in Africa, where Trump's decision has created an "inexplicably cruel situation," according to the Center for Global Development (CGD). "It is hard to fathom that the administration set out to destabilize poor African countries and unclear what they hope to gain," wrote CGD researchers. The tariffs have effectively tanked the African Growth & Opportunity Act (AGOA), which allowed duty-free imports to the US for 32 countries and was credited with helping economic growth. Lesotho and Madagascar could be among the Trump tariffs' biggest losers, CGD predicted. Amid existential financial worries in the international aid sector—triggered by Trump's closure of USAID—economists have also raised the possibility of a global trade war, with far-reaching ramifications for inflation and the cost of living worldwide.

Israel has been imposing a total blockade on aid entering the Gaza Strip since March 2, raising fears of a return to violence, and of a rapid further deterioration in the dire humanitarian situation in the devastated enclave. The move is intended to pressure Hamas to accept a temporary extension of the first phase of the three-stage ceasefire deal that went into effect on Jan. 19, while giving the Palestinian group little in return. The second phase of the deal was supposed to see Israel and Hamas hammer out a plan for Gaza's post-war governance. But Israeli Prime Minister Benjamin Netanyahu has instead repeatedly expressed support for US President Trump's widely condemned proposal to expel the 2.1 million Palestinian residents of Gaza and take control of the territory. Arab leaders meeting in Cairo on March 4 endorsed a $53 billion reconstruction and post-war governance plan as a counter-proposal to Trump's vision, but it was immediately rejected by the US and Israel. Even before assistance was cut off, Palestinians in Gaza said the dramatic increase in aid entering the enclave during the first phase of the deal brought less relief than they had hoped.

Amnesty International called Feb. 28 for the immediate release of both Israeli and foreign civilians held hostage by Hamas, and of all Palestinians arbitrarily detained by Israel. The organization said that the release of hostages and prisoners should not be conditional upon the result of the next phase of ceasefire negotiations between Hamas and Israel. There are at least 59 hostages remaining in Gaza, the majority of whom are Israelis. Meanwhile, there are more than 4,000 Palestinians held in detention in Israel without charge or trial, which Amnesty called a violation of international law.

Three weeks after US President Donald Trump's order to freeze foreign aid, Syrians are already seeing medical clinics providing urgent assistance close, water distributions slow down, and bread distribution in many displacement camps grind to a halt. After nearly 14 years of war, the UN estimates that 16.5 million people across Syria need some sort of aid. While the December overthrow of President Bashar al-Assad is beginning to change the way aid works in the country, the need for widespread relief for those dealing with severe poverty, food insecurity, and mass internal displacement has been unrelenting.

The Sudanese army appears close to retaking the capital city Khartoum from the paramilitary-turned-rebel Rapid Support Forces (RSF) as momentum continues to swing in its favor following nearly two years of conflict. Reports suggest the army has been advancing on multiple fronts, having broken a bruising siege on its Khartoum headquarters last month. It has also won back significant territory in other parts of central Sudan, including Gezira state. Military control, however, has come at a significant cost, with the UN reporting that soldiers and allied militia have been carrying out summary executions of civilians they accuse of being RSF collaborators. Workers in self-organized "mutual aid" groups—the backbone of the humanitarian response in Sudan—have also been targeted in the reprisals.